Efficacy and feasibility of vein of Marshall ethanol infusion during persistent atrial fibrillation ablation: A systematic review and meta‐analysis

Background Catheter ablation (CA) is currently used to treat persistent atrial fibrillation (PeAF). However, its effectiveness is limited. This study aimed to estimate the effectiveness of the vein of Marshall absolute ethanol injection (VOM‐EI) for PeAF ablation. Hypothesis Adjunctive vein of Marshall ethanol injection (VOM‐EI) strategies are more effective than conventional catheter ablation (CA) and have similar safety outcomes. Methods We extensively searched the literature for studies evaluating the effectiveness and safety of VOM‐EI + CA compared with CA alone. The primary endpoint was the rate of acute bidirectional block of the isthmus of the mitral annulus (MIBB). The secondary endpoints were atrial fibrillation (AF) or atrial tachycardia (AT) recurrence over 30 seconds after a 3‐month blanking period. Weighted pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs) were calculated using a random effects model. Results Based on the selection criteria, nine studies were included in this systematic review, including patients with AF (n = 2508), persistent AF (n = 1829), perimitral flutter (n = 103), and perimitral AT (n = 165). There were 1028 patients in the VOM‐EI + CA group and 1605 in the CA alone group. The VOM‐EI + CA group showed a lower rate of AF/AT relapse (RR = 0.70; 95% CI = 0.53–0.91; p = .008) and a higher rate of acute MIBB (RR = 1.29; 95% CI = 1.11–1.50; p = .0007) than the CA alone group. Conclusion Our meta‐analysis revealed that adjunctive VOM‐EI strategies are more effective than conventional CA and have similar safety outcomes. Efficacy and feasibility of vein of Marshall ethanol infusion. Through literature search and meta‐analysis, it was found that adjunctive vein of Marshall ethanol injection (VOM‐EI) strategies are more effective than conventional catheter ablation (CA) and have similar safety outcomes.