Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary...

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Veröffentlicht in:Cell systems 2023-04, Vol.14 (4), p.252-257
Hauptverfasser: Adler, Frederick R., Anderson, Alexander R.A., Bhushan, Abhinav, Bogdan, Paul, Bravo-Cordero, Jose Javier, Brock, Amy, Chen, Yun, Cukierman, Edna, DelGiorno, Kathleen E., Denis, Gerald V., Ferrall-Fairbanks, Meghan C., Gartner, Zev Jordan, Germain, Ronald N., Gordon, Deborah M., Hunter, Ginger, Jolly, Mohit Kumar, Karacosta, Loukia Georgiou, Mythreye, Karthikeyan, Katira, Parag, Kulkarni, Rajan P., Kutys, Matthew L., Lander, Arthur D., Laughney, Ashley M., Levine, Herbert, Lou, Emil, Lowenstein, Pedro R., Masters, Kristyn S., Pe’er, Dana, Peyton, Shelly R., Platt, Manu O., Purvis, Jeremy E., Quon, Gerald, Richer, Jennifer K., Riddle, Nicole C., Rodriguez, Analiz, Snyder, Joshua C., Lee Szeto, Gregory, Tomlin, Claire J., Yanai, Itai, Zervantonakis, Ioannis K., Dueck, Hannah
Format: Artikel
Sprache:eng
Schlagworte:
Communication
Humans
Mass Behavior
Neoplasms
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Zusammenfassung:Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions. Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.
ISSN:2405-4712
2405-4720
2405-4720
DOI:10.1016/j.cels.2023.03.002