Age‐specific reference intervals for liver function tests in healthy neonates, infants, and young children in Iran

Background The reference intervals (RIs) for liver function tests (LFTs) were determined in Iranian children for the first time. Methods A total of 344 healthy pediatrics aged 3 days to 30 months old were recruited. Serum levels of ALT, AST, ALP, direct bilirubin, and total bilirubin were measured....

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Veröffentlicht in:	Journal of clinical laboratory analysis 2023-12, Vol.37 (23-24), p.e24995-n/a
Hauptverfasser:	Badakhshan, Seyede Negin, Ghazizadeh, Hamideh, Mohammadi‐Bajgiran, Maryam, Esmaily, Habibollah, Khorasani, Mahdiyeh Yaghooti, Bohn, Mary Kathryn, Pashirzad, Mehran, Khodabandeh, Atieh Kamel, Zadeh, Sara Ghazi, Alami‐Arani, Iman, Rahimi, Hamidreza, Ferns, Gordon A., Boskabadi, Hassan, Assaran‐Darban, Reza, Adeli, Khosrow, Ghayour‐Mobarhan, Majid
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Bilirubin biochemical markers Child development Children CLSI Ep28‐A3 guidelines Cross-sectional studies Disease Enzymes Health care Infants Liver liver function tests Medical laboratories Metabolism Neonates pediatric Pediatrics Physiology Questionnaires reference intervals Sample size Serum levels Statistical analysis
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Zusammenfassung:	Background The reference intervals (RIs) for liver function tests (LFTs) were determined in Iranian children for the first time. Methods A total of 344 healthy pediatrics aged 3 days to 30 months old were recruited. Serum levels of ALT, AST, ALP, direct bilirubin, and total bilirubin were measured. RIs were determined using CLSI Ep28‐A3 guidelines. Results All analytes demonstrated age‐specific differences except AST. ALT and ALP demonstrated significantly elevated levels in infants 0 to
ISSN:	0887-8013 1098-2825
DOI:	10.1002/jcla.24995