Effect of coinfections on neurocognitive functioning among people with clade C HIV infection in Zambia

Despite the fact that many coinfections in people with HIV (PWH) are treatable or suppressible, they may still impact neurocognitive (NC) functioning. Here, we aim to evaluate the presence of latent/treated coinfections and their association with NC functioning in a cohort of PWH in Zambia. We carried out a cross-sectional, nested study involving 151 PWH with viral suppression, and a normative sample of 324 adults without HIV. Plasma samples from PWH who underwent a comprehensive NC assessment were evaluated for the presence of treated/latent coinfections that are common in Zambia. Information about treated pulmonary tuberculosis (TB) was obtained from participants’ clinical charts. Overall, PWH differed significantly from the HIV seronegatives on all neuropsychological domains except for fine motor control. ANOVA comparisons of all 3 HIV + groups’ demographically corrected mean NC T -scores showed that the HIV + /TB + group had the poorest NC functioning in the following domains: executive functioning ( F = 4.23, p = 0.02), working memory ( F = 5.05, p = 0.002), verbal fluency ( F = 4.24, p = 0.006), learning ( F = 11.26, p