Sugar-free synapses run on mitochondrial Sirtuin 3

Sugar-free synapses run on mitochondrial Sirtuin 3

Metabolic plasticity of neurons ensures their activity continues when glucose is limited. Walsh and Simon discuss new work by Ashrafi and colleagues (https://doi.org/10.1083/jcb.202305048) that finds Sirtuin 3 directs local metabolic adaptation at synapses during sustained glucose deprivation.

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Veröffentlicht in:The Journal of cell biology 2024-01, Vol.223 (1), p.1
Hauptverfasser: Walsh, Alexander P, Simon, David J
Format: Artikel
Sprache:eng
Schlagworte:
Glucose - metabolism
Mitochondria
Neurons - metabolism
Sirtuin 3 - genetics
Sirtuin 3 - metabolism
Spotlight
Synapses
Synapses - metabolism
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Zusammenfassung:Metabolic plasticity of neurons ensures their activity continues when glucose is limited. Walsh and Simon discuss new work by Ashrafi and colleagues (https://doi.org/10.1083/jcb.202305048) that finds Sirtuin 3 directs local metabolic adaptation at synapses during sustained glucose deprivation.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202312035