Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertension

Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertension

Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide significance, DNMT3A and FES. A total of 42 genes had an uncorrected p value

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Veröffentlicht in:Pulse 2023-01, Vol.11 (1), p.9-16
1. Verfasser: Curtis, David
Format: Artikel
Sprache:eng
Schlagworte:
asxl1
dbh
dnmt3a
exome
fes
gucy1a1
gucy1b1
hypertension
inppl1
npr1
Research Article
smad6
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Zusammenfassung:Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide significance, DNMT3A and FES. A total of 42 genes had an uncorrected p value
ISSN:2235-8676
2235-8668
DOI:10.1159/000535157