Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists

While the primary pathology of Alzheimer's disease (AD) is defined by brain deposition of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, chronic inflammation has emerged as an important factor in AD etiology. Upregulated cell surface expression of the receptor for advanced glycation en...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2023-11, Vol.24 (22), p.e202300503-e202300503
Hauptverfasser:	Waugh, Mihyun Lim, Wolf, Lauren M, Turner, James P, Phillips, Lauren N, Servoss, Shannon L, Moss, Melissa A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Antagonists Blood-brain barrier Brain Cell surface Cytokines Glycosylation HMGB1 protein Humans Immune response Inflammation Inflammatory response Innate immunity Ligands Lipopolysaccharides Neurodegenerative diseases Neurofibrillary tangles Neuroinflammatory Diseases Peptoids - pharmacology Permeability Proteolysis Receptor for Advanced Glycation End Products - metabolism Receptor for Advanced Glycation End Products - therapeutic use Receptors S100b protein Tau protein Toxicity β-Amyloid
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