Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, th...

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Veröffentlicht in:Euro surveillance : bulletin européen sur les maladies transmissibles 2023-09, Vol.28 (37)
Hauptverfasser: Maubaret, Clara, Caméléna, François, Mrimèche, Manel, Braille, Aymeric, Liberge, Mathilde, Mainardis, Mary, Guillaume, Clémence, Noel, Franck, Bébéar, Cécile, Molina, Jean-Michel, Lot, Florence, Chazelle, Emilie, Berçot, Béatrice
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Antimicrobial agents
Drug resistance
Genomes
Heterosexuality
Mutation
Rapid Communication
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Zusammenfassung:We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA -60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2023.28.37.2300456