Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis

The phenotypes of VITT were defined in 220 patients in the United Kingdom who presented a median of 14 days after the first ChAdOx1 nCoV-19 vaccination. Half had cerebral venous sinus thrombosis, a third of whom also had intracranial hemorrhage. Mortality was 22%. Intravenous immune globulin may rev...

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Veröffentlicht in:	The New England journal of medicine 2021-10, Vol.385 (18), p.1680-1689
Hauptverfasser:	Pavord, Sue, Scully, Marie, Hunt, Beverley J, Lester, William, Bagot, Catherine, Craven, Brian, Rampotas, Alex, Ambler, Gareth, Makris, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Antibodies Anticoagulants Anticoagulation Autoantibodies - blood Cardiology ChAdOx1 nCoV-19 Coagulation Coronavirus Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - adverse effects Critical Care Female Fibrinogen Hematology Hemorrhage Hospitals Humans Idiopathic thrombocytopenic purpura Immunization Immunoglobulins, Intravenous - therapeutic use Infectious Disease Intracranial Hemorrhages - etiology Intracranial Hemorrhages - mortality Laboratories Male Middle Aged Mortality Multivariate Analysis Oncology Original Patients Platelet Count Platelet Factor 4 - immunology Platelets Prospective Studies Public health Pulmonary Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - mortality Purpura, Thrombocytopenic, Idiopathic - therapy Risk Factors Severe acute respiratory syndrome coronavirus 2 Thrombocytopenia Thromboembolism Thrombosis Thrombosis - drug therapy Thrombosis - etiology Thrombosis - mortality United Kingdom - epidemiology Vaccination Vaccines Young Adult
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Zusammenfassung:	The phenotypes of VITT were defined in 220 patients in the United Kingdom who presented a median of 14 days after the first ChAdOx1 nCoV-19 vaccination. Half had cerebral venous sinus thrombosis, a third of whom also had intracranial hemorrhage. Mortality was 22%. Intravenous immune globulin may reverse VITT.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2109908