ANT1 and the SASP: Beyond the Bioenergetic Void

Rangarajan discusses the study by Sui et al that explores the role of adenine nucleotide translocase 1 (ANT1) in idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disease characterized by lung scarring and no known cure. They investigate the relationship between ANT1 expression and cell...

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Veröffentlicht in:American journal of respiratory cell and molecular biology 2023-11, Vol.69 (5), p.495-496
1. Verfasser: Rangarajan, Sunad
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Sprache:eng
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Zusammenfassung:Rangarajan discusses the study by Sui et al that explores the role of adenine nucleotide translocase 1 (ANT1) in idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disease characterized by lung scarring and no known cure. They investigate the relationship between ANT1 expression and cellular senescence in IPF. They found that ANT1 expression is decreased in the lungs of IPF patients, specifically in alveolar epithelial cells. Knockdown of ANT1 in human lung epithelial cell lines resulted in increased senescence markers. They also showed that loss of ANT1 led to worsened lung fibrosis and inflammation in mouse models. They observed metabolic alterations in the cells with ANT1 silencing, including a decreased nicotinamide adenine dinucleotide (NAD)-NADH ratio. Interestingly, loss of ANT1 did not lead to a decrease in total cellular adenosine triphosphate (ATP), but rather an increase in ATP concentrations associated with increased mitochondrial oxygen consumption rate and glycolytic flux. They suggest that ANT1-related metabolic and bioenergetic imbalance may contribute to cellular senescence in IPF. Further investigation is needed to understand the mechanisms underlying this relationship and explore potential therapeutic strategies for IPF.
ISSN:1044-1549
1535-4989
1535-4989
DOI:10.1165/rcmb.2023-0264ED