Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Biochemical response is an important prognostic indicator in chronic hepatitis B (CHB) patients receiving nucleotide/nucleoside analogues (NAs). However, the effects of air pollution in alanine aminotransferase (ALT) normalization remain elusive. This longitudinal study recruited 80 hepatitis B e an...

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Veröffentlicht in:Medicine (Baltimore) 2023-10, Vol.102 (43), p.e34276-e34276
Hauptverfasser: Jang, Tyng-Yuan, Ho, Chi-Chang, Wu, Chih-Da, Dai, Chia-Yen, Chen, Pau-Chung
Format: Artikel
Sprache:eng
Schlagworte:
Air Pollution - adverse effects
Alanine Transaminase
Antiviral Agents - therapeutic use
DNA, Viral
Female
Hepatitis B e Antigens
Hepatitis B virus - genetics
Hepatitis B, Chronic - drug therapy
Humans
Longitudinal Studies
Male
Nucleosides - therapeutic use
Nucleotides - therapeutic use
Observational Study
Ozone - therapeutic use
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Zusammenfassung:Biochemical response is an important prognostic indicator in chronic hepatitis B (CHB) patients receiving nucleotide/nucleoside analogues (NAs). However, the effects of air pollution in alanine aminotransferase (ALT) normalization remain elusive. This longitudinal study recruited 80 hepatitis B e antigen-negative CHB patients who received NAs. ALT levels were measured during the first year of anti-hepatitis B virus therapy. Normal ALT levels were defined as 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000034276