Association Between Monocyte-to-High-Density Lipoprotein (HDL) Cholesterol Ratio and Proteinuria in Patients With Type 2 Diabetes Mellitus: A Prospective Observational Study

BackgroundDiabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. “Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decreas...

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Veröffentlicht in:Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9), p.e45783-e45783
Hauptverfasser: D, Yashilha, SK, Shini Rubina, R, Nanda Kumar, PA, Anuba
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Sprache:eng
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Zusammenfassung:BackgroundDiabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. “Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decrease in glomerular filtration rate (GFR) are associated with DN along with elevated blood pressure and end-stage renal disease (ESRD). The purpose of this study is to analyze the prognostic significance of the monocyte-to-high-density lipoprotein (HDL) cholesterol ratio (MHR) in DN patients.Materials and methodsThis prospective observational study was carried out over a period of 1.5 years, with patients being followed up for three months. One hundred twenty participants were enrolled and allotted into groups based on the measure of urine albumin-to-creatinine ratio (UACR). The participants were categorized into healthy individuals, normoalbuminuric diabetic patients, microalbuminuric diabetic patients, and macroalbuminuric diabetic patients group. The MHR, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were estimated and compared between the baseline measurements.ConclusionThe MHR, NLR, and PLR showed a positive correlation with UACR levels which could serve as an inflammatory marker and be used as an inexpensive and accessible prognostic marker in DN patients.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45783