Active efflux of norfloxacin by Bacteroides fragilis

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the effl...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 1998-08, Vol.42 (8), p.2119-2121
Hauptverfasser:	MIYAMAE, S, NIKAIDO, H, TANAKA, Y, YOSHIMURA, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - physiology Bacteroides fragilis - drug effects Bacteroides fragilis - metabolism Biological and medical sciences Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Carrier Proteins - physiology Drug Resistance, Microbial Mechanisms of Resistance Medical sciences Membrane Transport Proteins Microbial Sensitivity Tests Norfloxacin - pharmacokinetics Norfloxacin - pharmacology Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.42.8.2119