Diabetes and the risk of cirrhosis and HCC: An analysis of the UK Biobank

Diabetes increases the risk of cirrhosis and HCC. We aimed to assess such associations given different diabetes statuses. We included 449,497 participants in the UK Biobank cohort (mean age 56.7±8.0 y; 45.5% male) and assessed the association between preclinical diabetes (prediabetes, having a high risk of diabetes), clinical diabetes (presence, duration, or glycemic control of type 2 diabetes), and incident liver cirrhosis and HCC by the Cox regression. Liver diseases were ascertained through inpatient records and national death registration. Gene-environment interaction was examined using the polygenic risk scores of cirrhosis and HCC. Compared with normoglycemia, having