Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis

Background: Paramagnetic rim lesions (PRLs) are an imaging biomarker in multiple sclerosis (MS), associated with a more severe disease. Objectives: To determine quantitative magnetic resonance imaging (MRI) metrics of PRLs, lesions with diffuse susceptibility-weighted imaging (SWI)-hypointense signa...

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Veröffentlicht in:	Multiple sclerosis 2023-10, Vol.29 (11-12), p.1406-1417
Hauptverfasser:	Krajnc, Nik, Schmidbauer, Victor, Leinkauf, Joel, Haider, Lukas, Bsteh, Gabriel, Kasprian, Gregor, Leutmezer, Fritz, Kornek, Barbara, Rommer, Paulus Stefan, Berger, Thomas, Lassmann, Hans, Dal-Bianco, Assunta, Hametner, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Lesions Magnetic resonance imaging Multiple sclerosis Original Research Papers Substantia alba
Online-Zugang:	Volltext
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Zusammenfassung:	Background: Paramagnetic rim lesions (PRLs) are an imaging biomarker in multiple sclerosis (MS), associated with a more severe disease. Objectives: To determine quantitative magnetic resonance imaging (MRI) metrics of PRLs, lesions with diffuse susceptibility-weighted imaging (SWI)-hypointense signal (DSHLs) and SWI-isointense lesions (SILs), their surrounding periplaque area (PPA) and the normal-appearing white matter (NAWM). Methods: In a cross-sectional study, quantitative MRI metrics were measured in people with multiple sclerosis (pwMS) using the multi-dynamic multi-echo (MDME) sequence post-processing software “SyMRI.” Results: In 30 pwMS, 59 PRLs, 74 DSHLs, and 107 SILs were identified. Beside longer T1 relaxation times of PRLs compared to DSHLs and SILs (2030.5 (1519–2540) vs 1615.8 (1403.3–1953.5) vs 1199.5 (1089.6–1334.6), both p
ISSN:	1352-4585 1477-0970 1477-0970
DOI:	10.1177/13524585231197954