Evaluation of Nocturnal Symptoms in Chinese Parkinson’s Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study

Background: Nocturnal symptoms have a significant effect on the quality of life in Parkinson’s disease (PD) patients. Objective: This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD patients. Methods: This multicenter cross-sectional study included 1,500 patients with primary PD from 18 centers in China was carried out between February 2019 and February 2020. Questionnaires including Parkinson’s disease sleep scale 2 (PDSS-2), Parkinson’s disease questionnaire 8 (PDQ-8), Beck depression inventory (BDI), and generalized anxiety disorder scale 7 (GAD-7) were used to assess nocturnal symptoms, quality of life, depression, and anxiety. Results: Among 1,500 Chinese PD patients, 576 (38.4%) reported nocturnal symptoms. Of them, 59.2% were older than 65 years. The PDQ-8 total score was higher in patients with nocturnal symptoms (p