Targeting the Inhibition of B‑Cell Lymphoma 2 Protein for the Treatment of Cancer

Targeting the Inhibition of B‑Cell Lymphoma 2 Protein for the Treatment of Cancer

The invention in this patent application relates to 1,3,4,7-tetrahydro-2H-pyrrolo­[3′,2′:5,6]­pyrido­[2,3-b]­[1,4]­oxazepine derivatives represented generally by Formula 1. These compounds are Bcl-2 inhibitors and may be useful for the treatment of chronic lymphocytic leukemia, small lymphocytic lym...

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Veröffentlicht in:ACS medicinal chemistry letters 2023-10, Vol.14 (10), p.1320-1322
1. Verfasser: Abdel-Magid, Ahmed F.
Format: Artikel
Sprache:eng
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Zusammenfassung:The invention in this patent application relates to 1,3,4,7-tetrahydro-2H-pyrrolo­[3′,2′:5,6]­pyrido­[2,3-b]­[1,4]­oxazepine derivatives represented generally by Formula 1. These compounds are Bcl-2 inhibitors and may be useful for the treatment of chronic lymphocytic leukemia, small lymphocytic lymphoma, and/or acute lymphocytic lymphoma.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.3c00379