Prognostic impact of soluble PD-L1 derived from tumor-associated macrophages in non-small-cell lung cancer

Prognostic impact of soluble PD-L1 derived from tumor-associated macrophages in non-small-cell lung cancer

Programmed cell death-ligand 1 (PD-L1) on tumor cells can be degraded to soluble form (sPD-L1) and enter circulation, however, the clinical significances of sPD-L1 in peripheral blood remains to be elucidated in non-small-cell lung cancer (NSCLC). We monitored plasma sPD-L1 levels during perioperati...

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Veröffentlicht in:Cancer Immunology, Immunotherapy Immunotherapy, 2023-11, Vol.72 (11), p.3755-3764
Hauptverfasser: Teramoto, Koji, Igarashi, Tomoyuki, Kataoka, Yoko, Ishida, Mitsuaki, Hanaoka, Jun, Sumimoto, Hidetoshi, Daigo, Yataro
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cancer Research
Cell death
Immunology
Lung cancer
Macrophages
Medical prognosis
Medicine
Medicine & Public Health
Non-small cell lung carcinoma
Oncology
Patients
PD-L1 protein
Peripheral blood
Plasma
Prognosis
Small cell lung carcinoma
Surgery
Tumor cells
Tumors
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Zusammenfassung:Programmed cell death-ligand 1 (PD-L1) on tumor cells can be degraded to soluble form (sPD-L1) and enter circulation, however, the clinical significances of sPD-L1 in peripheral blood remains to be elucidated in non-small-cell lung cancer (NSCLC). We monitored plasma sPD-L1 levels during perioperative periods and evaluated PD-L1-positive cells in tumor tissues in patients with operable NSCLC. Then the correlation between preoperative plasma sPD-L1 levels and relapse-free survival (RFS) was analyzed retrospectively. In patients who underwent radical surgery ( n  = 61), plasma sPD-L1 levels (median; 63.5 pg/mL) significantly increased 1 month after surgery (72.2 pg/mL, P  
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-023-03527-y