T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Abstract Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU an...

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Veröffentlicht in:Clinical infectious diseases 2023-10, Vol.77 (8), p.1133-1136
Hauptverfasser: Iwase, Saori C, Edlefsen, Paul T, Bhebhe, Lynnette, Motsumi, Kesego, Moyo, Sikhulile, Happel, Anna-Ursula, Shao, Danica, Mmasa, Nicholas, Schenkel, Sara, Gasper, Melanie A, Dubois, Melanie, Files, Megan A, Seshadri, Chetan, Duffy, Fergal, Aitchison, John, Netea, Mihai G, Jao, Jennifer, Cameron, Donald W, Gray, Clive M, Jaspan, Heather B, Powis, Kathleen M
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
Child
HIV
HIV Infections - epidemiology
Humans
Infant
Latent Tuberculosis
Prevalence
Tuberculosis - prevention & control
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Zusammenfassung:Abstract Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9–18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciad356