Targeting leucine-rich repeat serine/threonine-protein kinase 2 sensitizes pancreatic ductal adenocarcinoma to anti-PD-L1 immunotherapy

Pancreatic ductal adenocarcinoma (PDAC) is not sensitive to immune checkpoint blockade therapy, and negative feedback of tumor immune evasion might be partly responsible. We isolated CD8+ T cells and cultured them in vitro. Proteomics analysis was performed to compare changes in Panc02 cell lines cu...

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Veröffentlicht in:	Molecular therapy 2023-10, Vol.31 (10), p.2929-2947
Hauptverfasser:	Sun, Kang, Zhang, Xiaozhen, Lao, Mengyi, He, Lihong, Wang, Sicheng, Yang, Hanshen, Xu, Jian, Tang, Jianghui, Hong, Zhengtao, Song, Jinyuan, Guo, Chengxiang, Li, Muchun, Liu, Xinyuan, Chen, Yan, Zhang, Hanjia, Zhou, Jingxing, Lin, Jieru, Zhang, Sirui, Hong, Yifan, Huang, Jinyan, Liang, Tingbo, Bai, Xueli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Disease Models, Animal Gene Expression Regulation, Neoplastic - drug effects Humans Immune Checkpoint Inhibitors - pharmacology Immunotherapy - methods immunotherapy inhibitor Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism LRRK2 Mice Original Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy PD-L1 PDAC Phosphorylation
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