SAT035 Oligonucleotide IMT504 Markedly Improves Metabolic Sindrome And Type 2 Diabetes In High-Fat Diet Fed Mice

Disclosure: L. Domé: None. J.M. Riaño Gomez: None. M.M. Bonaventura: None. M.O. Fernandez: None. A.D. Montaner: None. V.A. Lux-Lantos: None. M.S. Bianchi: None. We have shown that the immunomodulatory oligonucleotide IMT504 (IMT) improves glucose homeostasis in several animal models of type 1 diabet...

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Veröffentlicht in:	Journal of the Endocrine Society 2023-10, Vol.7 (Supplement_1)
Hauptverfasser:	Domé, Laila, Riaño Gomez, Juan Manuel, Marta Bonaventura, María, Olga Fernandez, Marina, Daniel Montaner, Alejandro, Adela Lux-Lantos, Victoria, Silvia Bianchi, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetes And Glucose Metabolism
Online-Zugang:	Volltext
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Zusammenfassung:	Disclosure: L. Domé: None. J.M. Riaño Gomez: None. M.M. Bonaventura: None. M.O. Fernandez: None. A.D. Montaner: None. V.A. Lux-Lantos: None. M.S. Bianchi: None. We have shown that the immunomodulatory oligonucleotide IMT504 (IMT) improves glucose homeostasis in several animal models of type 1 diabetes by regulating immunomodulatory factors and by improving beta-cell function. Here we evaluated the effects of IMT in a murine model of metabolic syndrome and type 2 diabetes induced by high-fat diet (HFD).Five weeks-old C57BL/6LP male mice were fed either standard diet (SD) or HFD (ResearchDiet, D12492) for 12 weeks. HFD mice showed higher non-fasting glycemia (NF-Gly: p
ISSN:	2472-1972 2472-1972
DOI:	10.1210/jendso/bvad114.903