THU034 Severe Obesity In Cushing´s Disease In A Tertiary Center: Current Prevalence And Diagnostic Implications

Disclosure: B.M. Mascarenhas-Nakano: None. S.R. Correa-Silva: None. P.F. Santos-Neto: None. L.C. Portari: None. J. Abucham: None. Introduction: The prevalence of obesity in the general population has increased dramatically and severe obesity (SO) has become more frequent. Weight gain and obesity are common features of endogenous hypercortisolism but prevalence of SO in that condition was reportedly low in the past. Under the current "obesity epidemics", however, the prevalence of SO in patients with hypercortisolism has not been reassessed. Coexistence of both conditions may have diagnostic and therapeutic implications. Aims: To calculate prevalence of SO (BMI≥40kg/m2) in patients recently diagnosed with Cushing’s disease (CD), the most common form of endogenous hypercortisolism, and to describe/compare their characteristics with CD patients without SO. Patients and Methods: We retrospectively evaluated 68 sequential patients (59 F) with surgically proven CD (2000-2020). Disease severity was classified by a clinical score. Urinary free cortisol (UFC) [ratio to upper limit of normality (ULN)], late-night salivary cortisol (LNSC) and 1mg dexamethasone suppression test (DST) were analyzed. Statistics: Student´s, Mann Whitney, Chi-square, Fisher´s, Spearman, and Pearson tests. Results: mean±SD. P