FRI030 The Clinical Significance Of The Oxidative Status Evaluation Among Insulin Resistant Overweight And Obese Patients

Disclosure: A. Popławska-Kita: None. A. Buczyńska: None. E. Duraj: None. I. Sidorkiewicz: None. K. Łuka: None. K. Siewko: None. A. Adamska: None. A. Krętowski: None. Insulin resistance is a prevalent syndrome, developing and occurring simultaneously with weight gain, considering as predisposing factor for type 2 diabetes mellitus (T2DM), frequently resulting from metabolic syndrome development. Despite significant progress in the treatment of overweight and obesity, these patients are still at risk of developing chronic complications related to insulin resistance, such as T2DM and cardiovascular diseases, which are a significant clinical problem. In the pathogenesis of complications of insulin resistance among obese and overweight patients, an increasing role is attributed to oxidative stress. In physiological conditions reactive oxygen species (ROS) are formed from molecular oxygen in the cellular respiration process, but in concentrations exceeding the physiological are leading to the oxidative damage of macromolecules, such as: proteins, lipids, DNA. Furthermore, ROS may cause insulin resistance in the peripheral tissues by affecting various points in insulin receptor signal transduction increasing the risk of continued further weight gain. In this study, oxidative status among insulin resistant obese and overweight patients was determined. For the purpose of this study, 50 patients with obesity and insulin resistance (BMI>30), 50 overweight patients with insulin resistance (BMI>25) and 50 healthy volunteers (BMI