Identifying the causal relationship between sedentary behavior and heart failure: Insights from a Mendelian randomization study and mediation analysis

BackgroundObservational studies have revealed that a lack of physical exercise may be linked to a higher risk of heart failure (HF). Here, the causal relationship between sedentary behavior (SB) and HF was investigated using Mendelian randomization (MR).HypothesisSB was considered as an important ri...

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Veröffentlicht in:	Clinical cardiology (Mahwah, N.J.) N.J.), 2023-09, Vol.46 (9), p.1082-1089
Hauptverfasser:	Zheng, Xifeng, Liu, Manqi, Wu, Zijun, Jia, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavior Biobanks Body mass index Cardiac arrhythmia Cardiovascular disease Clinical Investigations Coronary vessels Coronaviruses Datasets Diabetes Energy consumption Epidemiology Genomes Heart failure Hypertension Metabolism Mortality Obesity Pulmonary embolisms Quality of life Screen time Sedentary behavior Sensitivity analysis Variables Vein & artery diseases
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Zusammenfassung:	BackgroundObservational studies have revealed that a lack of physical exercise may be linked to a higher risk of heart failure (HF). Here, the causal relationship between sedentary behavior (SB) and HF was investigated using Mendelian randomization (MR).HypothesisSB was considered as an important risk factor of HF.MethodsSingle nucleotide polymorphisms with a genome-wide statistical significance threshold of
ISSN:	0160-9289 1932-8737
DOI:	10.1002/clc.24101