Young-onset Rectal Cancer: Unique Tumoral Microbiome and Correlation with Response to Neoadjuvant Therapy

External exposures, the host, and the microbiome interact in oncology. We aimed to investigate tumoral microbiomes in young-onset rectal cancers (YORCs) for profiles potentially correlative with disease etiology and biology. YORC is rapidly increasing, with 1 in 4 new rectal cancer cases occurring u...

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Veröffentlicht in:Annals of surgery 2023-10, Vol.278 (4), p.538-548
Hauptverfasser: White, Michael G., Damania, Ashish, Alshenaifi, Jumanah, Sahasrabhojane, Pranoti, Peacock, Oliver, Losh, Jillian, Wong, Matthew C, Lutter-Berkova, Zuzana, Chang, George J., Futreal, Andrew, Wargo, Jennifer A., Ajami, Nadim J., Kopetz, Scott, You, Y. Nancy
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Sprache:eng
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Zusammenfassung:External exposures, the host, and the microbiome interact in oncology. We aimed to investigate tumoral microbiomes in young-onset rectal cancers (YORCs) for profiles potentially correlative with disease etiology and biology. YORC is rapidly increasing, with 1 in 4 new rectal cancer cases occurring under the age of 50 years. Its etiology is unknown. YORC (
ISSN:0003-4932
1528-1140
1528-1140
DOI:10.1097/SLA.0000000000006015