Tumor microenvironmental nutrients, cellular responses, and cancer

Over the last two decades, the rapidly expanding field of tumor metabolism has enhanced our knowledge of the impact of nutrient availability on metabolic reprogramming in cancer. Apart from established roles in cancer cells themselves, various nutrients, metabolic enzymes, and stress responses are key to the activities of tumor microenvironmental immune, fibroblastic, endothelial, and other cell types that support malignant transformation. In this article, we review our current understanding of how nutrient availability affects metabolic pathways and responses in both cancer and “stromal” cells, by dissecting major examples and their regulation of cellular activity. Understanding the relationship of nutrient availability to cellular behaviors in the tumor ecosystem will broaden the horizon of exploiting novel therapeutic vulnerabilities in cancer. [Display omitted] In this review, Lobel et al. summarize the current understanding of the metabolic requirements for the functions of multiple types of cells in the tumor microenvironment, including tumor, immune, stromal, and endothelial cells; as well as the metabolic interplay between these diverse cell types.