Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)

To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association. Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized...

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Veröffentlicht in:	Clinical cancer research 2023-07, Vol.29 (14), p.2621-2630
Hauptverfasser:	Wang, Qiao-Li, Ma, Chao, Yuan, Chen, Shi, Qian, Wolpin, Brian M, Zhang, Yin, Fuchs, Charles S, Meyer, Jeffrey, Zemla, Tyler, Cheng, En, Kumthekar, Priya, Guthrie, Katherine A, Couture, Felix, Kuebler, Philip, Kumar, Pankaj, Tan, Benjamin, Krishnamurthi, Smitha, Goldberg, Richard M, Venook, Alan, Blanke, Charles, Shields, Anthony F, O'Reilly, Eileen M, Meyerhardt, Jeffrey A, Ng, Kimmie
Format:	Artikel
Sprache:	eng
Schlagworte:	C-Reactive Protein Colonic Neoplasms Disease-Free Survival Humans Interleukin-6 Vitamin D Vitamins
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Zusammenfassung:	To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association. Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed until 2020. Cox regressions were used to examine associations between plasma 25(OH)D and disease-free survival (DFS), overall survival (OS), and time to recurrence (TTR). Mediation analysis was performed for circulating inflammatory biomarkers of C-reactive protein (CRP), IL6, and soluble TNF receptor 2 (sTNF-R2). Vitamin D deficiency [25(OH)D
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-23-0447