Association between SARS-CoV-2 infections during pregnancy and preterm live birth

We examined associations between mild or asymptomatic prenatal SARS-CoV-2 infection and preterm live birth in a prospective cohort study. During August 2020-October 2021, pregnant persons were followed with systematic surveillance for RT-PCR or serologically confirmed SARS-CoV-2 infection until preg...

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Veröffentlicht in:	Influenza and other respiratory viruses 2023-09, Vol.17 (9), p.e13192
Hauptverfasser:	Mohanty, Sarita, Tita, Alan T, Varner, Michael, Stockwell, Melissa S, Newes-Adeyi, Gabriella, Battarbee, Ashley N, Reichle, Lawrence, Morrill, Tyler, Daugherty, Michael, Mourad, Mirella, Silverio Francisco, Raul A, Woodworth, Kate, Wielgosz, Kristina, Galang, Romeo, Maniatis, Pete, Semenova, Vera, Dawood, Fatimah S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age groups Antigens Asymptomatic Birth Childbirth & labor Confidence intervals COVID-19 COVID-19 - epidemiology COVID-19 vaccines Data collection Enrollments Female Gestational diabetes Hazard assessment Humans Hypertension Immunization Infant, Newborn Infections Live Birth Medical laboratories Medical records Pregnancy Premature birth Premature Birth - epidemiology Prospective Studies Questionnaires Respiratory diseases Sample size SARS-CoV-2 Self report Serology Severe acute respiratory syndrome coronavirus 2 Short Communication Short Communications Statistical analysis Surveillance Viruses Vitamins
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Zusammenfassung:	We examined associations between mild or asymptomatic prenatal SARS-CoV-2 infection and preterm live birth in a prospective cohort study. During August 2020-October 2021, pregnant persons were followed with systematic surveillance for RT-PCR or serologically confirmed SARS-CoV-2 infection until pregnancy end. The association between prenatal SARS-CoV-2 infection and preterm birth was assessed using Cox proportional-hazards regression. Among 954 pregnant persons with a live birth, 185 (19%) had prenatal SARS-CoV-2 infection and 123 (13%) had preterm birth. The adjusted hazard ratio for the association between SARS-CoV-2 infection and preterm birth was 1.28 (95% confidence interval 0.82-1.99, = 0.28), although results did not reach statistical significance.
ISSN:	1750-2640 1750-2659 1750-2659
DOI:	10.1111/irv.13192