Immunity to pathogenic fungi in the eye
Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role...
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| Veröffentlicht in: | Seminars in immunology 2023-05, Vol.67, p.101753-101753, Article 101753 |
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| container_title | Seminars in immunology |
| container_volume | 67 |
| creator | Abbondante, Serena Leal, Sixto M. Clark, Heather L. Ratitong, Bridget Sun, Yan Ma, Li-Jun Pearlman, Eric |
| description | Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production. |
| doi_str_mv | 10.1016/j.smim.2023.101753 |
| format | Article |
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This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. 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This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.</description><subject>Aspergillus</subject><subject>Candida</subject><subject>Cornea</subject><subject>Cornea - microbiology</subject><subject>Cornea - pathology</subject><subject>Cytokines</subject><subject>Fungal infection</subject><subject>Fungi</subject><subject>Fusarium</subject><subject>Fusarium - physiology</subject><subject>Humans</subject><subject>IL-1 alpha</subject><subject>IL-1 beta</subject><subject>Innate immunity</subject><subject>Keratitis</subject><subject>Keratitis - microbiology</subject><subject>Keratitis - pathology</subject><subject>NADPH oxidase</subject><subject>Neutrophil</subject><subject>Neutrophils</subject><subject>Nutritional immunity</subject><subject>Ocular infection</subject><subject>Reactive oxygen species</subject><issn>1044-5323</issn><issn>1096-3618</issn><issn>1096-3618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-AQ-Sm15SZ7Mf2YAgUvwoFLzoedluJu2WfNRsUui_NyG16MXTzOy88-7MQ8g1hSkFKu83U1-4YhpBxPqHWLATMqaQyJBJqk77nPNQsIiNyIX3GwBgXNFzMmIxSFAgx-R2XhRt6Zp90FTB1jTraoWls0HWlisXuDJo1hjgHi_JWWZyj1eHOCGfL88fs7dw8f46nz0tQsuFbMJISWko2ER1paAiXQompOGpVFJwAQmjwloFHJPEpIrHbImcJwCpZBnjyCbkcfDdtssCU4tlU5tcb2tXmHqvK-P0307p1npV7TQF0V0k4s7h7uBQV18t-kYXzlvMc1Ni1XodKaCJolKwThoNUltX3teYHf-hoHvEeqN7xLpHrAfE3dDN7w2PIz9MO8HDIMCO085hrb11WFpMXY220Wnl_vP_BkLlivU</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Abbondante, Serena</creator><creator>Leal, Sixto M.</creator><creator>Clark, Heather L.</creator><creator>Ratitong, Bridget</creator><creator>Sun, Yan</creator><creator>Ma, Li-Jun</creator><creator>Pearlman, Eric</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0137-7582</orcidid></search><sort><creationdate>20230501</creationdate><title>Immunity to pathogenic fungi in the eye</title><author>Abbondante, Serena ; Leal, Sixto M. ; Clark, Heather L. ; Ratitong, Bridget ; Sun, Yan ; Ma, Li-Jun ; Pearlman, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-2866a10c98456515db5356a4d68654509315cc804e99ad8473be44900d63f34e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aspergillus</topic><topic>Candida</topic><topic>Cornea</topic><topic>Cornea - microbiology</topic><topic>Cornea - pathology</topic><topic>Cytokines</topic><topic>Fungal infection</topic><topic>Fungi</topic><topic>Fusarium</topic><topic>Fusarium - physiology</topic><topic>Humans</topic><topic>IL-1 alpha</topic><topic>IL-1 beta</topic><topic>Innate immunity</topic><topic>Keratitis</topic><topic>Keratitis - microbiology</topic><topic>Keratitis - pathology</topic><topic>NADPH oxidase</topic><topic>Neutrophil</topic><topic>Neutrophils</topic><topic>Nutritional immunity</topic><topic>Ocular infection</topic><topic>Reactive oxygen species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbondante, Serena</creatorcontrib><creatorcontrib>Leal, Sixto M.</creatorcontrib><creatorcontrib>Clark, Heather L.</creatorcontrib><creatorcontrib>Ratitong, Bridget</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Ma, Li-Jun</creatorcontrib><creatorcontrib>Pearlman, Eric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbondante, Serena</au><au>Leal, Sixto M.</au><au>Clark, Heather L.</au><au>Ratitong, Bridget</au><au>Sun, Yan</au><au>Ma, Li-Jun</au><au>Pearlman, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunity to pathogenic fungi in the eye</atitle><jtitle>Seminars in immunology</jtitle><addtitle>Semin Immunol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>67</volume><spage>101753</spage><epage>101753</epage><pages>101753-101753</pages><artnum>101753</artnum><issn>1044-5323</issn><issn>1096-3618</issn><eissn>1096-3618</eissn><abstract>Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. 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| identifier | ISSN: 1044-5323 |
| ispartof | Seminars in immunology, 2023-05, Vol.67, p.101753-101753, Article 101753 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aspergillus Candida Cornea Cornea - microbiology Cornea - pathology Cytokines Fungal infection Fungi Fusarium Fusarium - physiology Humans IL-1 alpha IL-1 beta Innate immunity Keratitis Keratitis - microbiology Keratitis - pathology NADPH oxidase Neutrophil Neutrophils Nutritional immunity Ocular infection Reactive oxygen species |
| title | Immunity to pathogenic fungi in the eye |
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