Immunity to pathogenic fungi in the eye

Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Seminars in immunology 2023-05, Vol.67, p.101753-101753, Article 101753
Hauptverfasser:	Abbondante, Serena, Leal, Sixto M., Clark, Heather L., Ratitong, Bridget, Sun, Yan, Ma, Li-Jun, Pearlman, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus Candida Cornea Cornea - microbiology Cornea - pathology Cytokines Fungal infection Fungi Fusarium Fusarium - physiology Humans IL-1 alpha IL-1 beta Innate immunity Keratitis Keratitis - microbiology Keratitis - pathology NADPH oxidase Neutrophil Neutrophils Nutritional immunity Ocular infection Reactive oxygen species
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.
ISSN:	1044-5323 1096-3618 1096-3618
DOI:	10.1016/j.smim.2023.101753