First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial

Abstract Background We evaluated the pharmacokinetics of tenofovir alafenamide fumarate (TAF) and tenofovir in a subset of African children enrolled in the CHAPAS-4 trial. Methods Children aged 3–15 years with human immunodeficiency virus infection failing first-line antiretroviral therapy were rand...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2023-09, Vol.77 (6), p.875-882
Hauptverfasser:	Waalewijn, Hylke, Szubert, Alexander J, Wasmann, Roeland E, Wiesner, Lubbe, Chabala, Chishala, Bwakura-Dangarembizi, Mutsa, Makumbi, Shafic, Nangiya, Joan, Mumbiro, Vivian, Mulenga, Veronica, Musiime, Victor, Monkiewicz, Lara N, Griffiths, Anna L, Bamford, Alasdair, Doerholt, Katja, Denti, Paolo, Burger, David M, Gibb, Diana M, McIlleron, Helen M, Colbers, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Antiviral Agents - therapeutic use Atazanavir Sulfate - therapeutic use Child Darunavir - therapeutic use Emtricitabine - therapeutic use Fumarates - therapeutic use HIV Infections - drug therapy Humans Lopinavir - therapeutic use Major Protease Inhibitors - therapeutic use Ritonavir - therapeutic use Tenofovir - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Background We evaluated the pharmacokinetics of tenofovir alafenamide fumarate (TAF) and tenofovir in a subset of African children enrolled in the CHAPAS-4 trial. Methods Children aged 3–15 years with human immunodeficiency virus infection failing first-line antiretroviral therapy were randomized to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to World Health Organization (WHO)–recommended weight bands: 120/15 mg in children weighing 14 to
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciad267