The effects of severe mixed environmental pollution on human chromosomes
Cytogenetic studies were conducted on healthy young mothers, shortly after child birth, in two residential areas each with an approximate population of 20,000, situated about 25 km from Athens, Greece. One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi,...
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Veröffentlicht in: | Journal of medical genetics 1986-10, Vol.23 (5), p.452-455 |
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description | Cytogenetic studies were conducted on healthy young mothers, shortly after child birth, in two residential areas each with an approximate population of 20,000, situated about 25 km from Athens, Greece. One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi, is relatively free of pollution. Chromosomal aberrations were investigated in 16 women from each area in 72 hour lymphocyte cultures treated with gentian violet to enhance any chromosomal instability induced by the pollution. The women were of a comparable socioeconomic level, aged between 20 and 31 years, and with no history of factors associated with mutagenesis. Venous blood samples were taken from the two groups and processed concurrently. The slides were coded and examined independently by two observers, who were unaware of the source of the samples. A total of 100 cells was examined on each sample. The two observers obtained highly comparable results. Women from Elefsis had an average of 0.42 anomalies per cell and those from Koropi had 0.39. The absence of a statistically significant difference between the two groups clearly shows that the severe mixed environmental pollution of Elefsis has no significant visible effect on human chromosomes in most residents. However, two Elefsis women had abnormal results and could be at risk. Their presence is not sufficient to raise significantly their group's average, but the induction by pollution of an increased rate of chromosomal anomalies in only a few people at risk could account for the known association between urban residence and cancer mortality. |
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One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi, is relatively free of pollution. Chromosomal aberrations were investigated in 16 women from each area in 72 hour lymphocyte cultures treated with gentian violet to enhance any chromosomal instability induced by the pollution. The women were of a comparable socioeconomic level, aged between 20 and 31 years, and with no history of factors associated with mutagenesis. Venous blood samples were taken from the two groups and processed concurrently. The slides were coded and examined independently by two observers, who were unaware of the source of the samples. A total of 100 cells was examined on each sample. The two observers obtained highly comparable results. Women from Elefsis had an average of 0.42 anomalies per cell and those from Koropi had 0.39. The absence of a statistically significant difference between the two groups clearly shows that the severe mixed environmental pollution of Elefsis has no significant visible effect on human chromosomes in most residents. However, two Elefsis women had abnormal results and could be at risk. Their presence is not sufficient to raise significantly their group's average, but the induction by pollution of an increased rate of chromosomal anomalies in only a few people at risk could account for the known association between urban residence and cancer mortality.</description><identifier>ISSN: 0022-2593</identifier><identifier>ISSN: 1468-6244</identifier><identifier>EISSN: 1468-6244</identifier><identifier>DOI: 10.1136/jmg.23.5.452</identifier><identifier>PMID: 3783622</identifier><identifier>CODEN: JMDGAE</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cells, Cultured ; Chemical mutagenesis ; Chromosome Aberrations ; Chromosomes, Human - drug effects ; Environmental Pollution ; Female ; Greece ; Humans ; Karyotyping ; Lymphocytes - cytology ; Medical sciences ; Pregnancy ; Toxicology</subject><ispartof>Journal of medical genetics, 1986-10, Vol.23 (5), p.452-455</ispartof><rights>1987 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Oct 1986</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-ae41507552ab6835d10ddb864bac428bad685266317248d98dc0c8a671dc83843</citedby><cites>FETCH-LOGICAL-b506t-ae41507552ab6835d10ddb864bac428bad685266317248d98dc0c8a671dc83843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1049783/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1049783/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8248375$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3783622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katsantoni, A</creatorcontrib><creatorcontrib>Nakou, S</creatorcontrib><creatorcontrib>Antoniadou-Koumatou, I</creatorcontrib><creatorcontrib>Côté, G B</creatorcontrib><title>The effects of severe mixed environmental pollution on human chromosomes</title><title>Journal of medical genetics</title><addtitle>J Med Genet</addtitle><description>Cytogenetic studies were conducted on healthy young mothers, shortly after child birth, in two residential areas each with an approximate population of 20,000, situated about 25 km from Athens, Greece. One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi, is relatively free of pollution. Chromosomal aberrations were investigated in 16 women from each area in 72 hour lymphocyte cultures treated with gentian violet to enhance any chromosomal instability induced by the pollution. The women were of a comparable socioeconomic level, aged between 20 and 31 years, and with no history of factors associated with mutagenesis. Venous blood samples were taken from the two groups and processed concurrently. The slides were coded and examined independently by two observers, who were unaware of the source of the samples. A total of 100 cells was examined on each sample. The two observers obtained highly comparable results. Women from Elefsis had an average of 0.42 anomalies per cell and those from Koropi had 0.39. The absence of a statistically significant difference between the two groups clearly shows that the severe mixed environmental pollution of Elefsis has no significant visible effect on human chromosomes in most residents. However, two Elefsis women had abnormal results and could be at risk. Their presence is not sufficient to raise significantly their group's average, but the induction by pollution of an increased rate of chromosomal anomalies in only a few people at risk could account for the known association between urban residence and cancer mortality.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Chemical mutagenesis</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human - drug effects</subject><subject>Environmental Pollution</subject><subject>Female</subject><subject>Greece</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Lymphocytes - cytology</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Toxicology</subject><issn>0022-2593</issn><issn>1468-6244</issn><issn>1468-6244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEUhUVoSB2nu24LAw1kk3H0lrwpBOddk2zcbIVG0sTjjkauNGOSf18FG9NuAhfu4nyce-4B4CuCE4QIv1j5lwkmEzahDB-AEaJclhxT-gmMIMS4xGxKPoPjlFYQIiIQPwJHREjCMR6Bu8XSFa6unelTEeoiuY2LrvDNq7OF6zZNDJ13Xa_bYh3aduib0BV5loPXXWGWMfiQgnfpBBzWuk3uy26Pwa-b68Xsrpw_3d7PLudlxSDvS-0oYlAwhnXFJWEWQWsryWmlDcWy0pZLhjknSGAq7VRaA43UXCBrJJGUjMGPre96qLyzJmeLulXr2Hgd31TQjfpf6ZqlegkbhSCd5q-zwfedQQx_Bpd6tQpD7HJmhYSAjFMh3qnzLWViSCm6en8BQfVeu8q1K0wUU7n2jH_7N9Ue3vWc9dOdrpPRbR11Z5q0x2T-lQiWsXKLNal3r3tZx9-Kiwyox-eZmpHFw094JZXI_NmWr_zq44B_AZ96psI</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Katsantoni, A</creator><creator>Nakou, S</creator><creator>Antoniadou-Koumatou, I</creator><creator>Côté, G B</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>19861001</creationdate><title>The effects of severe mixed environmental pollution on human chromosomes</title><author>Katsantoni, A ; Nakou, S ; Antoniadou-Koumatou, I ; Côté, G B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-ae41507552ab6835d10ddb864bac428bad685266317248d98dc0c8a671dc83843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Chemical mutagenesis</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human - drug effects</topic><topic>Environmental Pollution</topic><topic>Female</topic><topic>Greece</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Lymphocytes - cytology</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katsantoni, A</creatorcontrib><creatorcontrib>Nakou, S</creatorcontrib><creatorcontrib>Antoniadou-Koumatou, I</creatorcontrib><creatorcontrib>Côté, G B</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katsantoni, A</au><au>Nakou, S</au><au>Antoniadou-Koumatou, I</au><au>Côté, G B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of severe mixed environmental pollution on human chromosomes</atitle><jtitle>Journal of medical genetics</jtitle><addtitle>J Med Genet</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>23</volume><issue>5</issue><spage>452</spage><epage>455</epage><pages>452-455</pages><issn>0022-2593</issn><issn>1468-6244</issn><eissn>1468-6244</eissn><coden>JMDGAE</coden><abstract>Cytogenetic studies were conducted on healthy young mothers, shortly after child birth, in two residential areas each with an approximate population of 20,000, situated about 25 km from Athens, Greece. One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi, is relatively free of pollution. Chromosomal aberrations were investigated in 16 women from each area in 72 hour lymphocyte cultures treated with gentian violet to enhance any chromosomal instability induced by the pollution. The women were of a comparable socioeconomic level, aged between 20 and 31 years, and with no history of factors associated with mutagenesis. Venous blood samples were taken from the two groups and processed concurrently. The slides were coded and examined independently by two observers, who were unaware of the source of the samples. A total of 100 cells was examined on each sample. The two observers obtained highly comparable results. Women from Elefsis had an average of 0.42 anomalies per cell and those from Koropi had 0.39. The absence of a statistically significant difference between the two groups clearly shows that the severe mixed environmental pollution of Elefsis has no significant visible effect on human chromosomes in most residents. However, two Elefsis women had abnormal results and could be at risk. Their presence is not sufficient to raise significantly their group's average, but the induction by pollution of an increased rate of chromosomal anomalies in only a few people at risk could account for the known association between urban residence and cancer mortality.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3783622</pmid><doi>10.1136/jmg.23.5.452</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Biological and medical sciences Cells, Cultured Chemical mutagenesis Chromosome Aberrations Chromosomes, Human - drug effects Environmental Pollution Female Greece Humans Karyotyping Lymphocytes - cytology Medical sciences Pregnancy Toxicology |
title | The effects of severe mixed environmental pollution on human chromosomes |
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