Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples

Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples

Immature platelets (IP) are the youngest circulating platelets, released from megakaryocytes, and demonstrating increased dimensions, significant RNA content, and enhanced activity. Immature platelet research focuses on a differential diagnostic help in patients with thrombocytopenia. The objectives...

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Veröffentlicht in:Journal of clinical laboratory analysis 2023-07, Vol.37 (13-14), p.e24946-e24946
Hauptverfasser: Noel, Marc Michel, Feugray, Guillaume, Kasonga, Fiston, Buchonnet, Gérard, Daliphard, Sylvie, Barbay, Virginie, Bera, Elsa, Le Cam Duchez, Véronique, Billoir, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulants
Blood platelets
Blood tests
Bone marrow
Citric acid
Edetic acid
Hematology
Megakaryocytes
Platelets
Standardization
Thrombocytopenia
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Zusammenfassung:Immature platelets (IP) are the youngest circulating platelets, released from megakaryocytes, and demonstrating increased dimensions, significant RNA content, and enhanced activity. Immature platelet research focuses on a differential diagnostic help in patients with thrombocytopenia. The objectives of this study were to compare the variability of IP in citrate and EDTA samples, and to determine stability over time. Fifty-six patients were included for comparison between EDTA and citrate whole blood sample collection. Among the patients, 28 had thrombocytopenia (platelet count 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24946