Are alterations in running biomechanics associated with running injuries? A systematic review with meta-analysis

•There is a weak association between running biomechanics and running-related injuries.•Very limited evidence supporting that running biomechanics is associated with injuries.•There is significant heterogeneity of methods in running biomechanics studies. No systematic review has investigated the main biomechanical variables as predictors of running-related injuries. To investigate the main biomechanical variables associated with running-related injuries. Medline via PubMed, EMBASE, SPORTDiscus, Web of Science, and CINAHL were searched from inception until 1 November 2021. Each study included must have investigated the association of at least one biomechanical variable (kinetics, kinematics, electromyography, or pressure distribution) with running injuries. The meta-analysis was conducted, and a modified version of the Downs and Black Quality Index was used for methodological quality evaluation. Across the 82 studies included, 5465 runners were investigated. The meta-analysis was conducted with 11 biomechanical variables from 51 articles (n=2395). The peak hip adduction angle was the sole biomechanical variable associated with running injury and was found to be higher in injured runners (0.57, 95% CI 0.21, 0.94) compared to uninjured runners. However, this result was highly influenced by two studies (out of five studies) conducted by the same group of authors. Clinicians, coaches, and runners should be aware that minimal evidence supports that alterations of running biomechanics are associated with running-related injuries. Heterogeneity in evaluation conditions and inconsistency in the naming and definitions of biomechanical variables make definitive conclusions challenging. PROSPERO, CRD42017068839