Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1‐CXCR2 axis

Intratumor bacteria modify the tumor immune microenvironment and influence outcomes of various tumors. Periodontal pathogen Fusobacterium nucleatum has been detected in pancreatic cancer tissues and is associated with poor prognosis. However, it remains unclear how F. nucleatum affects pancreatic ca...

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Veröffentlicht in:	Cancer science 2023-09, Vol.114 (9), p.3666-3678
Hauptverfasser:	Hayashi, Masataka, Ikenaga, Naoki, Nakata, Kohei, Luo, Haizhen, Zhong, PingShan, Date, Satomi, Oyama, Koki, Higashijima, Nobuhiro, Kubo, Akihiro, Iwamoto, Chika, Torata, Nobuhiro, Abe, Toshiya, Yamada, Yutaka, Ohuchida, Kenoki, Oda, Yoshinao, Nakamura, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine signalling Bacteria Cancer therapies CD8 antigen CD8-Positive T-Lymphocytes - pathology Cell growth Chemokines Cloning Colorectal cancer Colorectal Neoplasms - pathology CXCL1 CXCR2 CXCR2 protein Cytokines Esophagus Fusobacterium nucleatum Genomes Laboratories Ligands Lymphatic system Lymphocytes T Medical prognosis Metastasis Mice Microbiota Microenvironments Original ORIGINAL ARTICLES Pancreatic cancer Pancreatic Neoplasms Paracrine signalling Suppressor cells tumor immune microenvironment Tumor Microenvironment Tumors
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