Vascular risk factors and astrocytic marker for the glymphatic system activity

Objectives Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is an established method measuring perivascular glymphatic activity, but comprehensi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Radiologia medica 2023-09, Vol.128 (9), p.1148-1161
Hauptverfasser: Wei, Yi-Chia, Hsu, Chih-Chin Heather, Huang, Wen-Yi, Lin, Chemin, Chen, Chih-Ken, Chen, Yao-Liang, Chen, Pin-Yuan, Shyu, Yu-Chiau, Lin, Ching-Po
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objectives Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is an established method measuring perivascular glymphatic activity, but comprehensive investigations into its influential factors are lacking. Methods Community-dwelling older adults underwent brain MRI scans, neuropsychiatric, and multi-domain assessments. Blood biomarker tests included glial fibrillary acidic protein (GFAP) for astrocyte injury. Results In 71 enrolled participants, the DTI-ALPS index was associated with modifiable factors, including lipid profile (high-density lipoprotein, r  = 0.396; very-low-density lipoprotein, r  =  − 0.342), glucose intolerance (diabetes mellitus, standardized mean difference (SMD) = 0.7662; glycated hemoglobin, r  =  − 0.324), obesity (body mass index, r  =  − 0.295; waist, r  =  − 0.455), metabolic syndrome (SMD =   − 0.6068), cigarette-smoking (SMD =  − 0.6292), and renal clearance (creatinine, r  =  − 0.387; blood urea nitrogen, r  =  − 0.303). Unmodifiable associative factors of DTI-ALPS were age ( r  =  − 0.434) and sex (SMD = 1.0769) (all p  
ISSN:1826-6983
0033-8362
1826-6983
DOI:10.1007/s11547-023-01675-w