Renin-Angiotensin Inhibition and Outcomes in HFrEF and Advanced Kidney Disease

Renin-angiotensin system inhibitors improve outcomes in patients with heart failure with reduced ejection fraction (HFrEF). However, less is known about their effectiveness in patients with HFrEF and advanced kidney disease. In the Medicare-linked Organized Program to Initiate Lifesaving Treatment i...

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Veröffentlicht in:	The American journal of medicine 2023-07, Vol.136 (7), p.677-686
Hauptverfasser:	Patel, Samir, Lam, Phillip H., Kanonidis, Evangelos I., Ahmed, Amiya A., Raman, Venkatesh K., Wu, Wen-Chih, Rossignol, Patrick, Arundel, Cherinne, Faselis, Charles, Kanonidis, Ioannis E., Deedwania, Prakash, Allman, Richard M., Sheikh, Farooq H., Fonarow, Gregg C., Pitt, Bertram, Ahmed, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced kidney disease Aged Angiotensin Receptor Antagonists - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Angiotensins - therapeutic use Female Heart failure Heart Failure - drug therapy Hospitalization Humans Kidney Diseases - drug therapy Male Medicare Mortality Renin Renin-angiotensin system inhibitors Stroke Volume United States
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Beschreibung
Zusammenfassung:	Renin-angiotensin system inhibitors improve outcomes in patients with heart failure with reduced ejection fraction (HFrEF). However, less is known about their effectiveness in patients with HFrEF and advanced kidney disease. In the Medicare-linked Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF), 1582 patients with HFrEF (ejection fraction ≤40%) had advanced kidney disease (estimated glomerular filtration rate
ISSN:	0002-9343 1555-7162 1555-7162
DOI:	10.1016/j.amjmed.2023.03.017