Survival after combined resection and ablation is not inferior to that after resection alone, in patients with four or more colorectal liver metastases
Purpose Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer. Multimodal treatment strategies are frequently necessary to achieve total tumor elimination. This study examines the efficacy of liver resection combined with local ablative th...
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Veröffentlicht in: | Langenbeck's archives of surgery 2023-08, Vol.408 (1), p.343-343, Article 343 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose
Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer. Multimodal treatment strategies are frequently necessary to achieve total tumor elimination. This study examines the efficacy of liver resection combined with local ablative therapy in comparison to liver resection only, in the treatment of patients with ≥ 4 CRLM.
Methods
This retrospective cohort study was conducted at the University Hospital RWTH Aachen, Germany. Patients with ≥ 4 CRLM in preoperative imaging, who underwent curative resection between 2010–2021, were included. Recurrent resections and deaths in the early postoperative phase were excluded. Ablation modalities included radiofrequency or microwave ablation, and irreversible electroporation. Differences in overall- (OS) and recurrence-free-survival (RFS) between patients undergoing combined resection-ablation vs. resection only, were examined.
Results
Of 178 included patients, 46 (27%) underwent combined resection-ablation and 132 (73%) resection only. Apart from increased rates of adjuvant chemotherapy in the first group (44% vs. 25%,
p
= 0.014), there were no differences in perioperative systemic therapy. Kaplan–Meier and log-rank test analyses showed no statistically significant differences in median OS (36 months for both,
p
= 0.638) or RFS (9 months for combined resection-ablation vs. 8 months,
p
= 0.921). Cox regression analysis showed a hazard ratio of 0.891 (
p
= 0.642) for OS and 0.981 (
p
= 0.924) for RFS, for patients undergoing resection only.
Conclusion
For patients with ≥ 4 CRLM, combined resection-ablation is a viable option in terms of OS and RFS. Therefore, combined resection-ablation should be considered for complete tumor clearance, in patients with multifocal disease. |
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ISSN: | 1435-2451 1435-2443 1435-2451 |
DOI: | 10.1007/s00423-023-03082-1 |