Protective properties of Spondias mombin Linn leaves on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-intoxicated rats

Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of Spondias mombin on redox status, cholinergic dysfunction and electrolyte disturbanc...

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Veröffentlicht in:Science progress (1916) 2021-04, Vol.104 (2), p.368504211011866
Hauptverfasser: Akinmoladun, Afolabi Clement, Adelabu, Adesola Adebusayo, Saliu, Ibrahim Olabayode, Adetuyi, Aanuoluwapo Ruth, Olaleye, Mary Tolulope
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Sprache:eng
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Zusammenfassung:Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of Spondias mombin on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-induced neurotoxicity in rats. Male Wistar rats were orally pre-treated with Spondias mombin methanol leaf extract (SMC) (50, 100 and 150 mg/kg), flavonoid-rich extract (SMF) (25, 50 and 75 mg/kg) or quercetin (20 mg/kg), followed by intraperitoneal administration of 2 mg/kg potassium cyanide. Cyanide intoxication caused brain damage in rats as echoed in the deleterious alterations to activities/levels of endogenous antioxidants and biomarkers/enzymes linked with electrolyte imbalance and neurotoxicity. Pre-treatment with SMC and SMF significantly attenuated these KCN-induced imbalances (p 
ISSN:0036-8504
2047-7163
DOI:10.1177/00368504211011866