Application of Metal–Organic Frameworks for Efficient Removal of Doxorubicin Hydrochloride: Removal Process Optimization and Biological Activity

This study looked at the doxorubicin hydrochloride (DOX) anticancer drug’s adsorption characteristics on a silver-based metal–organic framework (Ag-MOF). X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were used for the characterization of Ag-M...

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Veröffentlicht in:ACS omega 2023-08, Vol.8 (33), p.30374-30388
Hauptverfasser: Alkhamis, Kholood M., Aljohani, Meshari M., Ibarhiam, Saham F., Hameed, Yasmeen A. S., Abumelha, Hana M., Habeebullah, Turki M., El-Metwaly, Nashwa M.
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Sprache:eng
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Zusammenfassung:This study looked at the doxorubicin hydrochloride (DOX) anticancer drug’s adsorption characteristics on a silver-based metal–organic framework (Ag-MOF). X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were used for the characterization of Ag-MOF. The pore volume and surface area of Ag-MOF were determined through Brunauer–Emmett–Teller (BET) testing at 77 K to be 0.509 cm3/g and 676.059 m2/g, respectively. Adsorption at pH 6 was established to be the best for DOX compared to alkaline solution. Ag-MOF has a good capacity for eliminating DOX (1.85 mmol/g), according to adsorption experiments. From the adsorption results, we can find that Langmuir is the most fitted adsorption isotherm model and the pseudo-second order model best fitted the adsorption kinetics. The energy of activation for adsorption, which was determined to be 15.23 kJ/mol, also supported a chemisorption process. The mechanism of adsorption was evaluated, and details of all possible interactions between DOX and Ag-MOF were illustrated. On the other hand, while examining the impact of temperature, we identified the thermodynamic constraints as ΔG°, ΔH°, and ΔS° and confirmed that the reaction was an endothermic one and spontaneous. Even after numerous reuse cycles, the efficiency remained constant. The synthetic adsorbent was remarkably recyclable at a rate of more than 91.6%. By using the MTT assay, the cytotoxicity of the tested Ag-MOF and DOX@Ag-MOF against human breast cancer cells (MCF-7) was evaluated in vitro. The in vitro antimicrobial activity of Ag-MOF and DOX@Ag-MOF was also tested.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.3c03523