In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

•Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.•Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.•Molnupiravir might act on the replication phase of the ZIKV life cycle.

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Veröffentlicht in:Virologica Sinica 2023-08, Vol.38 (4), p.639-642
Hauptverfasser: Wang, Zhuang, Yang, Shaokang, Dai, Qingsong, Guo, Xiaojia, Li, Yuexiang, Li, Wei, Yang, Xiaotong, Yang, Jingjing, Yan, Xintong, Tao, Huimin, Luo, Chongda, Li, Song, Chen, Xingjuan, Cao, Ruiyuan, Zhong, Wu
Format: Artikel
Sprache:eng
Schlagworte:
Letter
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Zusammenfassung:•Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.•Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.•Molnupiravir might act on the replication phase of the ZIKV life cycle.
ISSN:1995-820X
1674-0769
1995-820X
DOI:10.1016/j.virs.2023.05.011