The NLRP3 inflammasome in viral infection (Review)

The NLRP3 inflammasome in viral infection (Review)

The interplay between pathogen and host determines the immune response during viral infection. The Nod‑like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL‑1β, which play an important role in the innate immune...

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Veröffentlicht in:Molecular medicine reports 2023-09, Vol.28 (3), Article 160
Hauptverfasser: Zheng, Qiaoli, Hua, Chunting, Liang, Qichang, Cheng, Hao
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Care and treatment
Cell receptors
Cytokines
Development and progression
Genetic aspects
Health aspects
Immune response
Inflammasomes
Inflammation
Innate immunity
Kinases
Mitochondrial DNA
Proteins
Pyrin protein
Review
Viral infections
Virus diseases
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Beschreibung
Zusammenfassung:The interplay between pathogen and host determines the immune response during viral infection. The Nod‑like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL‑1β, which play an important role in the innate immune responses. In the present review, the mechanisms of the NLR family pyrin domain containing 3 inflammasome activation and its dysregulation in viral infection were addressed.
ISSN:1791-2997
1791-3004
DOI:10.3892/mmr.2023.13047