Metabolic phenotyping of pilomotor seizures in autoimmune encephalitis

Objectives Ictal piloerection (IP) is an uncommon symptom in focal epilepsy and is associated with autoimmune encephalitis (AE). However, the networks involved in AE‐associated IP are still unclear. To have a better understanding of IP underlying mechanisms, the current study investigated whole‐brai...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2023-09, Vol.29 (9), p.2522-2529
Hauptverfasser:	Sun, Yueqian, Zhao, Xiaobin, Ai, Lin, Wang, Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Atrophy Autoantibodies Autoimmune diseases autoimmune encephalitis Convulsions & seizures Electroencephalography Encephalitis Epilepsy FDG‐PET Glutamic acid receptors (metabotropic) Immunotherapy LGI1 protein Magnetic resonance imaging Medical imaging Metabolic networks Metabolism Neuroimaging Neurological disorders Original pathological mechanism Patients Phenotyping pilomotor seizures Positron emission tomography Proteins Seizures Temporal gyrus Tomography γ-Aminobutyric acid B receptors
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Zusammenfassung:	Objectives Ictal piloerection (IP) is an uncommon symptom in focal epilepsy and is associated with autoimmune encephalitis (AE). However, the networks involved in AE‐associated IP are still unclear. To have a better understanding of IP underlying mechanisms, the current study investigated whole‐brain metabolic networks for the analysis of AE‐associated IP. Methods Patients with AE and IP diagnosed at our Institute between 2018 and 2022 were selected. We then investigated the brain regions associated with AE‐associated IP using positron emission tomography (PET). Anatomometabolic changes (interictal 18F fluorodeoxyglucose PET) in AE patients with IP were compared with those of AE patients of similar age without IP (p‐voxel
ISSN:	1755-5930 1755-5949
DOI:	10.1111/cns.14192