Metformin-Induced Receptor Turnover Alters Antibody Accumulation in HER-Expressing Tumors

Metformin has effects beyond its antihyperglycemic properties, including altering the localization of membrane receptors in cancer cells. Metformin decreases human epidermal growth factor receptor (HER) membrane density. Depletion of cell-surface HER decreases antibody-tumor binding for imaging and...

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Veröffentlicht in:	Journal of Nuclear Medicine 2023-08, Vol.64 (8), p.1195-1202
Hauptverfasser:	Panikar, Sandeep Surendra, Keltee, Nai, Berry, Na-Keysha, Shmuel, Shayla, Fisher, Zachary T, Brown, Emma, Zidel, Abbey, Mabry, Alex, Pereira, Patrícia M R
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antibodies Antibodies, Monoclonal - therapeutic use Antidiabetics Binding Cancer Cancer therapies Cell Line, Tumor Cell surface Depletion Endocytosis ErbB Receptors - metabolism Fractionation Growth factors HER protein Humans Imaging Immunofluorescence Localization Membranes Metformin Metformin - pharmacology Mice Neoplasms - diagnostic imaging Neoplasms - drug therapy Neoplasms - pathology Phosphorylation Positron emission Positron-Emission Tomography - methods Proteins Receptor density Receptor mechanisms Receptors Tumors Xenotransplantation
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