Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Lay Summary Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally indepen...

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Veröffentlicht in:Inflammatory bowel diseases 2023-08, Vol.29 (8), p.1347-1351
Hauptverfasser: te Groen, Maarten, Derikx, Lauranne A A P, van Lierop, Lisa, Ylstra, Bauke, Hoentjen, Frank, Nagtegaal, Iris D, Simmer, Femke
Format: Artikel
Sprache:eng
Schlagworte:
Clinical Brief Reports
Cohort Studies
Colorectal Neoplasms - etiology
Humans
Inflammatory Bowel Diseases - complications
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Zusammenfassung:Lay Summary Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.
ISSN:1078-0998
1536-4844
1536-4844
DOI:10.1093/ibd/izad112