Structural biology at the scale of proteomes

AlphaFold2 has already changed structural biology, but its true power may lie in how it changes the way we think about cells and organisms. Two studies broadly assess its utility and limitations in providing structural models to shed light in areas such as mutations, protein–protein interactions, an...

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Veröffentlicht in:	Nature structural & molecular biology 2023-02, Vol.30 (2), p.129-130
Hauptverfasser:	Bouatta, Nazim, AlQuraishi, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/470 631/553 Accuracy Binding sites Biochemistry Biological Microscopy Biology Biomedical and Life Sciences Computational Biology Life Sciences Machine learning Membrane Biology Molecular Biology Mutation News & Views news-and-views Phosphorylation Preprints Protein interaction Protein Structure Proteins Proteome Proteomes Proteomics Structural models
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Beschreibung
Zusammenfassung:	AlphaFold2 has already changed structural biology, but its true power may lie in how it changes the way we think about cells and organisms. Two studies broadly assess its utility and limitations in providing structural models to shed light in areas such as mutations, protein–protein interactions, and phosphorylation.
ISSN:	1545-9993 1545-9985 1545-9985
DOI:	10.1038/s41594-023-00924-w