Targeted Transcriptional Analysis of IgA Vasculitis, IgA Nephropathy, and IgA-Dominant Infection-Related Glomerulonephritis Reveals Both Distinct and Overlapping Immune Signatures

Skin IL-9, calprotectin, and KIR gene expression may be predictive of subsequent kidney involvement in patients with IgAV. Histologically similar patients with IgAN, IgAV, and IgA-IRGN can be distinguished by their immune transcriptomes. Kidney biopsies from patients with IgA-IRGN are enriched for t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Kidney360 2023-06, Vol.4 (6), p.e759-e768
Hauptverfasser:	Kung, Vanderlene L, Avasare, Rupali, Friedman, Marcia A, Koon, Stephanie Mengden, Neff, Tanaya L, Protzek, Sara, Corless, Christopher, Krajbich, Victoria, Setthavongsack, Naly, Ditmore, Rebecca, Woltjer, Randall, Andeen, Nicole K
Format:	Artikel
Sprache:	eng
Schlagworte:	Glomerular and Tubulointerstitial Diseases Glomerulonephritis, IGA - genetics Humans IgA Vasculitis Immunoglobulin A Original Investigation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Skin IL-9, calprotectin, and KIR gene expression may be predictive of subsequent kidney involvement in patients with IgAV. Histologically similar patients with IgAN, IgAV, and IgA-IRGN can be distinguished by their immune transcriptomes. Kidney biopsies from patients with IgA-IRGN are enriched for transcripts involved in granulocyte chemotaxis.
ISSN:	2641-7650 2641-7650
DOI:	10.34067/KID.0000000000000123