CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion

Screening of natural product extracts to find candidate compounds that increase mutant type IV collagen α 3,4,5 ( α 345(IV)) trimer secretion in Alport syndrome (AS). Cyclosporin A (CsA) and alisporivir (ALV) increase mutant α 345(IV) trimer secretion in AS. PPIF/cyclophilin D mediates the effect of...

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Veröffentlicht in:	Kidney360 2023-07, Vol.4 (7), p.909-917
Hauptverfasser:	Kuwazuru, Jun, Suico, Mary Ann, Omachi, Kohei, Kojima, Haruka, Kamura, Misato, Kaseda, Shota, Kawahara, Teppei, Hitora, Yuki, Kato, Hikaru, Tsukamoto, Sachiko, Wada, Mikiyo, Asano, Toshifumi, Kotani, Shunsuke, Nakajima, Makoto, Misumi, Shogo, Sannomiya, Yuya, Horizono, Jun, Koyama, Yuimi, Owaki, Aimi, Shuto, Tsuyoshi, Kai, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Basement Membrane Collagen Type IV - genetics Glomerular and Tubulointerstitial Diseases Humans Nephritis, Hereditary - drug therapy Nephritis, Hereditary - genetics Original Investigation
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Zusammenfassung:	Screening of natural product extracts to find candidate compounds that increase mutant type IV collagen α 3,4,5 ( α 345(IV)) trimer secretion in Alport syndrome (AS). Cyclosporin A (CsA) and alisporivir (ALV) increase mutant α 345(IV) trimer secretion in AS. PPIF/cyclophilin D mediates the effect of CsA and ALV on mutant trimer secretion.
ISSN:	2641-7650 2641-7650
DOI:	10.34067/KID.0000000000000134