Dual-tuned Coaxial-transmission-line RF coils with Independent Tuning Capabilities for X-nuclear Metabolic MRS Imaging at Ultrahigh Magnetic Fields

Information on the metabolism of tissues in both healthy and diseased states has potential for detecting tumors, neurodegeneration diseases, diabetes, and many metabolic disorders in biomedical studies. Hyperpolarized carbon-13 magnetic resonance imaging (13C-HPMRI) and deuterium metabolic imaging (2H-DMI) are two emerging X-nuclei used as practical imaging tools to investigate tissue metabolism. However due to their low gyromagnetic ratios ($\gamma_{13C}$ = 10.7 MHz/T; $\gamma_{2H}$ = 6.5 MHz/T) and natural abundance, such method required the use of a sophisticated dual-tuned radio frequency (RF) coil where the X-nucleus signal is associated with the proton signal used for anatomical reference. Here, we report a dual-tuned coaxial transmission line (CTL) RF coil agile for metabolite information operating at 7T with independent tuning capability. Analysis based on full-wave simulation has demonstrated how both resonant frequencies can be individually controlled by simply varying the constituent of the design parameters. A broadband tuning range capability is obtained, covering most of the X-nucleus signal, especially the 13C and 2H spectra at 7T. Numerical results has demonstrated the effectiveness of the magnetic field produced by the proposed dual-tuned 1H/13C and 1H/2H CTLs RF coils. Furthermore, in order to validate the feasibility of the proposed design, both dual-tuned CTLs prototypes are designed and fabricated using a semi-flexible RG-405 .086" coaxial cable and bench test results (scattering parameters and magnetic field efficiency/distributions) are successfully obtained.