Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study

Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study

Despite having the highest number of preterm births globally, no genomic study on preterm birth was previously published from India or other South-Asian countries. We conducted a genome-wide association (GWA) study of spontaneous preterm birth (sPTB) on 6211 women from India. We used a novel resampl...

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Veröffentlicht in:The Lancet regional health. Southeast Asia 2023-07, Vol.14, p.100190-100190, Article 100190
Hauptverfasser: Bhattacharjee, Esha, Thiruvengadam, Ramachandran, Ayushi, Das, Chitrarpita, Bal, Vineeta, Bhatnagar, Shinjini, Das, Bhabatosh, Desiraju, Bapu Koundinya, Kshetrapal, Pallavi, Misra, Sumit, Chandra Mouli Natchu, Uma, Rath, Satyajit, Sachdeva, Kanika, Sharma, Dharmendra, Singh, Amanpreet, Sopory, Shailaja, Wadhwa, Nitya, Maitra, Arindam, Majumder, Partha P., Maiti, Tushar K., Bahl, Monika, Bansal, Shubra, Mehta, Umesh, Sharma, Sunita, Sindhu, Brahmdeep, Arya, Sugandha, Bharti, Rekha, Chellani, Harish, Mittal, Pratima, Garg, Anju, Ramji, Siddharth, Khurana, Ashok, Tripathi, Reva, Gupta, Yashdeep, Hari, Smriti, Tandon, Nikhil, Gupta, Rakesh, Salunke, Dinakar M., Nair, Balakrish G., Kang, Gagandeep, Natchu, Uma Chandra Mouli, Majumder, Partha Pratim
Format: Artikel
Sprache:eng
Schlagworte:
Cluster file
GWAS
India
Maternal genome
Spontaneous preterm birth
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Zusammenfassung:Despite having the highest number of preterm births globally, no genomic study on preterm birth was previously published from India or other South-Asian countries. We conducted a genome-wide association (GWA) study of spontaneous preterm birth (sPTB) on 6211 women from India. We used a novel resampling procedure to identify the associated single nucleotide polymorphisms (SNPs) followed by haplotype association analysis and imputation. We found that 512 maternal SNPs were associated with sPTB (p 
ISSN:2772-3682
2772-3682
DOI:10.1016/j.lansea.2023.100190